Publications

For a complete list of publications, click here.

2020

Simkin A*, Geissler R, McIntyre ABR, Grimson A*. Evolutionary dynamics of microRNA target sites across vertebrate evolution. PLoS Genet. 2020 Feb 3;16(2):e1008285. doi: 10.1371/journal.pgen.1008285.

*Co-corresponding authors

2019

Singh P, Patel RK, Palmer N, Grenier JK, Paduch D, Kaldis P, Grimson A, Schimenti JC. CDK2 kinase activity is a regulator of male germ cell fate. Development. 2019 Nov 6;146(21). pii: dev180273. doi: 10.1242/dev.180273.

Paduch DA, Hilz S, Grimson A, Schlegel PN, Jedlicka AE, Wright WW. Aberrant gene expression by Sertoli cells in infertile men with Sertoli cell-only syndrome. PLoS One. 2019 May 9;14(5):e0216586. doi: 10.1371/journal.pone.0216586.

Vu LT, Peng B, Zhang DX, Ma V, Mathey-Andrews CA, Lam CK, Kiomourtzis T, Jin J, McReynolds L, Huang L, Grimson A, Cho WC, Lieberman J, Le MT. Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b. J Extracell Vesicles. 2019 Apr 14;8(1):1599680. doi: 10.1080/20013078.2019.1599680.

Webb LM, Oyesola OO, Früh SP, Kamynina E, Still KM, Patel RK, Peng SA, Cubitt  RL, Grimson A, Grenier JK, Harris TH, Danko CG, Tait Wojno ED. The Notch signaling pathway promotes basophil responses during helminth-induced type 2 inflammation. J Exp Med. 2019 Jun 3;216(6):1268-1279. doi: 10.1084/jem.20180131. 

Grive KJ, Hu Y, Shu E, Grimson A, Elemento O, Grenier JK, Cohen PE. Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during  postnatal testis maturation revealed by single-cell sequencing. PLoS Genet. 2019  Mar 20;15(3):e1007810. doi: 10.1371/journal.pgen.1007810.

Bertolet G, Kongchan N, Miller R, Patel RK, Jain A, Choi JM, Saltzman AB, Christenson A, Jung SY, Malovannaya A, Grimson A, Neilson JR. MiR-146a wild-type  3' sequence identity is dispensable for proper innate immune function in vivo. Life Sci Alliance. 2019 Feb 18;2(1). pii: e201800249. doi: 10.26508/lsa.201800249. Print 2019 Feb. PubMed PMID: 30777858; PubMed Central PMCID: PMC6379685. 

2018

Smith NL, Patel RK, Reynaldi A, Grenier JK, Wang J, Watson NB, Nzingha K, Yee  Mon KJ, Peng SA, Grimson A, Davenport MP, Rudd BD. Developmental Origin Governs CD8(+) T Cell Fate Decisions during Infection. Cell. 2018 Jun 28;174(1):117-130.e14. doi: 10.1016/j.cell.2018.05.029.



Geissler R, Grimson A. Characterizing mRNA Sequence Motifs in the 3'-UTR Using GFP Reporter Constructs. Methods Mol Biol. 2018;1720:77-88. doi: 10.1007/978-1-4939-7540-2_6. PubMed PMID: 29236252. 

2017

Hilz S, Fogarty EA, Modzelewski AJ, Cohen PE, Grimson A. Transcriptome profiling of the developing male germ line identifies the miR-29 family as a global regulator during meiosis. RNA Biol. 2017 Feb;14(2):219-235. doi: 10.1080/15476286.2016.1270002.

2016

Wang J, Wissink EM, Watson NB, Smith NL, Grimson A*, Rudd BD*. Fetal and adult progenitors give rise to unique populations of CD8+ T cells. Blood. 2016 Dec 29;128(26):3073-3082. doi: 10.1182/blood-2016-06-725366.

*Co-corresponding authors



Geissler R, Grimson A. A position-specific 3'UTR sequence that accelerates mRNA decay. RNA Biol. 2016 Nov;13(11):1075-1077.



Guo Y, Alexander K, Clark AG, Grimson A, Yu H. Integrated network analysis reveals distinct regulatory roles of transcription factors and microRNAs. RNA. 2016 Nov;22(11):1663-1672.

Hilz S, Modzelewski AJ, Cohen PE, Grimson A. The roles of microRNAs and siRNAs in mammalian spermatogenesis. Development. 2016 Sep 1;143(17):3061-73. doi: 10.1242/dev.136721. Review. PubMed PMID: 27578177; PubMed Central PMCID: PMC5047671. 

Geissler R, Simkin A, Floss D, Patel R, Fogarty EA, Scheller J, Grimson A. A  widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.  Genes Dev. 2016 May 1;30(9):1070-85. doi: 10.1101/gad.277392.116. PubMed PMID: 27151978; PubMed Central PMCID: PMC4863738. 

Wissink EM, Fogarty EA, Grimson A. High-throughput discovery of post-transcriptional cis-regulatory elements. BMC Genomics. 2016 Mar 3;17:177. doi: 10.1186/s12864-016-2479-7. PubMed PMID: 26941072; PubMed Central PMCID: PMC4778349. 



Vo TV, Das J, Meyer MJ, Cordero NA, Akturk N, Wei X, Fair BJ, Degatano AG, Fragoza R, Liu LG, Matsuyama A, Trickey M, Horibata S, Grimson A, Yamano H, Yoshida M, Roth FP, Pleiss JA, Xia Y, Yu H. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Cell. 2016 Jan 14;164(1-2):310-323. doi: 10.1016/j.cell.2015.11.037. PubMed PMID: 26771498;  PubMed Central PMCID: PMC4715267. 

2015

Smith NL, Wissink EM, Grimson A*, Rudd BD*. miR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cells. Sci Rep. 2015 Nov 9;5:16399. doi: 10.1038/srep16399. PubMed PMID: 26549197; PubMed Central PMCID: PMC4637875.

*Co-corresponding authors 



Wissink EM, Smith NL, Spektor R, Rudd BD*, Grimson A*. MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T Cells. Genetics. 2015 Nov;201(3):1017-30. doi: 10.1534/genetics.115.179176.

*Co-corresponding authors

Stepankiw N, Raghavan M, Fogarty EA, Grimson A*, Pleiss JA*. Widespread alternative and aberrant splicing revealed by lariat sequencing. Nucleic Acids Res. 2015 Sep 30;43(17):8488-501. doi: 10.1093/nar/gkv763.

*Co-corresponding authors

Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep;23(9):1465-74. doi: 10.1038/mt.2015.113.

Kristjánsdóttir K, Fogarty EA, Grimson A. Systematic analysis of the Hmga2 3' UTR identifies many independent regulatory sequences and a novel interaction between distal sites. RNA. 2015 Jul;21(7):1346-60. doi: 10.1261/rna.051177.115.

Modzelewski AJ, Hilz S, Crate EA, Schweidenback CT, Fogarty EA, Grenier JK, Freire R, Cohen PE*, Grimson A*. Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males. J Cell Sci. 2015 Jun 15;128(12):2314-27. doi:  10.1242/jcs.167148.

*Co-corresponding authors

Grimson A. Noncoding RNA: linking microRNAs to their targets. Nat Chem Biol.  2015 Feb;11(2):100-1. doi: 10.1038/nchembio.1741. PubMed PMID: 25602729. 

2014

Smith NL, Wissink E, Wang J, Pinello JF, Davenport MP, Grimson A, Rudd BD. Rapid proliferation and differentiation impairs the development of memory CD8+ T  cells in early life. J Immunol. 2014 Jul 1;193(1):177-84. doi: 10.4049/jimmunol.1400553.

2013

Guo Y, Wei X, Das J, Grimson A, Lipkin SM, Clark AG, Yu H. Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle. Am J Hum Genet. 2013 Jul 11;93(1):78-89. doi: 10.1016/j.ajhg.2013.05.022.

2012

Modzelewski AJ, Holmes RJ, Hilz S, Grimson A*, Cohen PE*. AGO4 regulates entry  into meiosis and influences silencing of sex chromosomes in the male mouse germline. Dev Cell. 2012 Aug 14;23(2):251-64. doi: 10.1016/j.devcel.2012.07.003.

*Co-corresponding authors

2011

Garcia DM, Baek D, Shin C, Bell GW, Grimson A, Bartel DP. Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs. Nat Struct Mol Biol. 2011 Sep 11;18(10):1139-46. doi: 10.1038/nsmb.2115. PubMed PMID: 21909094; PubMed Central PMCID: PMC3190056.

2010

Grimson A. A targeted approach to miRNA target identification. Nat Methods. 2010 Oct;7(10):795-7. doi: 10.1038/nmeth1010-795.

 

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